David Shapira

Institute of Cellular and Molecular Biosciences (ICaMB) Medical School Newcastle University Catherine Cookson Building Framlington Place Newcastle-upon-Tyne NE2 4HH


Dr Manolis Papamichos-Chronakis and Professor Francesco Falciani

I am fascinated by the complexity of epigenetic regulation of chromatin and the centrality of it to all cellular processes.

Investigating the role of INO80 and epigenetics in the regulation of autophagy 

The conserved chromatin remodeller INO80 is a highly conserved epigenetic regulator which is involved in nearly all nuclear processes. Our lab has recently shown that this complex is also involved in protein turnover, at least partially through regulating selective autophagy pathways. Selective autophagy is essential for eukaryotic cellular homeostasis and has consequences on ageing and cancer in higher eukaryotes. In spite of this, the epigenetic regulation controlling this process is poorly understood.

In my project I am investigating the regulation and crosstalk between chromatin and selective autophagy and the role of INO80 in this.

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